Controversial ‘three-parent baby’ fertility technique takes off in Mexico City

Sitting in his spotless office in the New Hope Fertility Clinic in Mexico City, soft music playing in the hallway in the background, Doctor Alejandro Chavez-Badiola demonstrates an affable smile. Three-parent newborns is not the title I would have chosen for the therapy, the clinic director says. But if the press had not dedicated it such an attractive title, the news of what were doing likely would not have had such an impact.

Indeed, three-parent newborn is easier to remember than mitochondrial replacing treatment( MRT ), a relatively new procedure offered to couples who want to reduce the chance of pass certain genetic disease onto their children.


It is controversial because the embryo takes eggs from two mothers.

Pregnancies through MRT, which is banned in the U.S ., are achieved by transferring the nucleus from a moms egg to a donor egg, which in turn had its nucleus removed. The new egg is then fertilized by the parents sperm and ultimately placed in the mothers uterus.

Mexico Citys New Hope is a branch of a namesake New York City fertility clinic founded by John Zhang in 2014. Critics say New Hope picked Mexico simply because of its weak regulatory framework.


Dr. Chavez-Badiola, a gynecologist and obstetrician trained in Mexico and the United Kingdom, told Fox News he hopes to apply MRT to 20 pregnancies in the first half of 2017. He would not disclose, however, how many three-way pregnancies are underway at this time.

The first three-parent baby was conceived in Mexicos New Hope in 2015 but being implemented in New York City last year. He was born to a Jordanian couple at risk of reproducing a rare disorder called Leigh disease, an incurable that can lead to small children demise within years from birth.

The Jordanian couple was treated in the New Hope clinic in Mexico by a U.S. squad led by Dr. Zhang. So far, the son appears to be healthy, according to New Hope, and the successful procedure resulted Chavez-Badiola and his peers to the conclusion that their work should be extended to a larger number of couples in Mexico.


It isnt the first mitochondrial replacing technique ever developed. Earlier procedures applied in the 1990 s yielded good results, but were different they transferred healthy mitochondria to the mothers egg. New Hopes technique is called spindle nuclear transfer and involves cutting-edge technology and equipment rarely seen in developing countries.

Aside from the morals, critics of MRT believe it is still far too early to consider the procedure to be safe. They worry that some defected mitochondria could be transferred with the mothers nucleus into the donor cell. According to the science publication Nature, some also are worried that New Hope has rushed into the wider be applied in the procedure.

The clinic, can be found in Polanco, one of the swankiest neighborhoods of the Mexican capital, is currently waiting for enough patients to achieve Chavez-Badiolas ambitious goal of 20 pregnancies. So far, he is principally counting on patients from abroad because Mexican couples are harder to find.

There are families in Mexico suspected of having mitochondrial cancers, but as far as I know there isnt anyone to offer them the means to diagnose, he said.

Nor is fund a number of problems, at the least in theory. According to Chavez-Badiola, the procedure isnt more expensive than a regular IVF-treatment. We first want to know if the technique can be replicated and devote us the results were hoping for, he said. Right now wed be willing to absorb the extra cost, as its a therapy that stems from extraordinary technology.

Chavez-Badiola recognise the criticisms, but counters them with the debate that he and his colleagues are on the vanguard of medical research, which always causes some discomfort.

Mitochondrial cancers arent illness that have been known for centuries. Theyre diagnosed through technologies that are relatively recent, he told Fox News. I believe that, if youre going to study such a thing, analyzing it alone has the potential of changing the style the medical profession acts.

Jan-Albert Hootsen is a freelance novelist based in Mexico City. Follow him on Twitter: @Jayhootsen

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